Treating Downs Syndrome, with stem cell transplantation

DOWN'S SYNDROME

Trisomy 21, Down's Syndrome or Mongolism, is the most frequent and best known chromosomal disorder with incidence of 1:700 live births. It is a disorder of the whole body involving primarily abnormalities of physical and mental development, with an added insult of marked weakness of the immune system:

  1. Somatic, gross motor, intellectual and mental development, are lagging behind norms, and more so with each passing day after birth,
  2. Nanism, hypothyreoidism, and adrenal insufficiency, are the result of endocrine abnormalities,
  3. Dysproportionate growth of face and cranium, not noticeable at birth, becomes more obvious with age as a result of cranial growth delays; brain growth is slowed down dyspropotionately as well: occipital and parietal lobes lag behind more than the other parts, but actually the cerebellum is the most affected,
  4. Mongoloid physiognomy becomes more noticeable with age,
  5. Delayed development of all mesenchymal structures causes immune system deficiency,
  6. There is no direct relationship between the degree of visible chromosomal damage and the delay of intellectual development,
  7. Nanism begins in infancy but becomes most pronounced during puberty.

Typical clinical findings are psychomotor retardation, growth delay, muscle hypotonia, joint hypermobility, as well as brachycephalia with flat occiput, dysplastic auricles, wide flat facies, mongoloid slant of eyes with epicanthus, Bruschfield corneal spots, button nose with a wide root, open mouth with macroglossia and lingua scrotalis, gothic palate, dental anomalies, pectus carinatum, absence of ribs, congenital heart defects, umbilical hernia, gastrointestinal stenoses, short and wide fingers, brachymesophalangia and clinodactyly of little fingers, and atypical dermatoglyphics.

There is an increased incidence of leukemias and immunological defects. At autopsy of adult Down's Syndrome patients, morphological and histochemical changes typical of Alzheimer disease are found in the brain.

Lifespan is shortened, but in absence of congenital heart defects and serious immunological deficiencies, Down's Syndrome patients can live up to 60 years of age.

There is no reproductive ability in complete Trisomy 21, but patients with mosaic forms of Trisomy 21 can be fertile and have normal offsprings.

The older the mother, the higher is the incidence of Trisomy 21 and all other chromosomal aberrations.

THERAPEUTIC PRINCIPLES

  1. regulation of endocrine balance, in particular hypothyroidism and lowered function of glucocorticoid portion of adrenal cortex,
  2. elimination of ever increasing delay in brain development,
  3. correction of immune system deficiency,
  4. repair of defects of supportive tissues of the body,
  5. total rehabilitation of all body systems, by physiotherapy, active exercise, speech therapy, occupational therapy, and all educational tools available,
  6. avoidance of therapeutic nihilism.

NUTRITION IS IMPORTANT

Correct nutrition, including yoghurt made by Acidophilus species, and mega-vitamin/mineral supplementation, are mandatory, in particular of vitamins A, B1 and B6. Enzymotherapy should be routinely used, in particular if the quality of nutrition lags.

Ultrafiltrates of animal fetal brain tissue should be given orally, or in suppositories, once a week between cell transplantation treatments.

A majority of patients, with a suspicion of hypothyroidism, even though the laboratory tests of thyroid function are within limits of normal, have to receive minimal doses of thyroid hormone.

Depending upon the experience of the treating physicians, Down's Syndrome patients may be given Phosphatidylcholine, Choline bitartrate, or Centrophenoxine, for a neurotransmitter function augmentation Piracetam has been shown to raise tryptophan levels in Down's Syndrome patients and the same applies to 5-hydroxytryptophan.

CELL TRANSPLANTATION

Since the brain is the most damaged organ, cell transplantation treatment is begun with implantation of brain cortex, diencephalon, mesencephalon, and hypothalamus. Subsequently, in every 4 months repeated implantations, cell transplants of spinal cord, cerebellum, occipital lobe of brain, temporal lobe of brain, frontal lobe of brain, and parietal lobe of brain, are selected as clinically necessary. In addition to cell transplants of various parts of brain:

  • cell transplants of thymus and adrenal cortex are advised for immune deficiency,
  • cell transplants of cartilage and placenta for achondroplasia-like condition,
  • cell transplants of thyroid and liver should be given once between 6th and 10th year of age,
  • cell transplants of adrenal cortex and ovary to girls should be given once between 6th and 10th year of life,
  • cell transplants of adrenal cortex and testis to boys should be given once between 8th and 10th year of life,
  • cell transplants of cardiomyoblasts, liver, lung, for heart defects,
  • cell transplants of intestine, exocrine pancreas, liver, for gastrointestinal damage,
  • cell transplants of placenta, lens, corpus vitreum, for early cataract.

Standard medical textbooks state that genetic and chromosomal diseases have no know treatment, with rare exceptions. In reality, there have been many publications from the university hospitals of Germany, USSR/Russia, Spain, and USA prior to 1957, etc., that report on the success in the treatment of many genetic and chromosomal diseases by a complex therapeutic protocol based on cell transplantation, so that therapeutic nihilism is not justified whatsoever.

Down's Syndrome has been a shining example. Schmid published data about his personal treatment of over 3,000 children with Down's Syndrome, whereby 25% of his patients were able to attend regular schools.

Published data prove the statistically significant improvement in height, skull circumference, index of brain volume, IQ and mental development, motor development. Among untreated children with Down's Syndrome 50-60% dies during the first 5 years of life due to intercurrent infections and cardiac failure, while the mortality of children treated in accordance with the described protocol is the same as in normal children. Typical features of Down's Syndrome become less pronounced with each subsequent cell transplantation treatment, and immune system deficiency is completely corrected. In all such cases cell transplantation has been carried out at an early age, or as soon as possible after the diagnosis was established. The earlier in life cell transplantation was carried out, the better was the outcome, while beyond certain age any such treatment was of questionable benefit: for example, to start cell transplantation for a child with Down's Syndrome beyond the age of 4 years was found to be of minor to minimal therapeutic benefit.

DR. E. MICHAEL MOLNAR'S OWN STUDY

Our own published study of the first 83 patients with Down's Syndrome in which we evaluated mental and psychological functions showed the following results. The percentage of younger Down's Syndrome children (up to 3.5 years of age) with mental development index of over 50 points increased from 17% before the 1st SCT, to 58% after the 1st SCT, and to 71% after the 2nd SCT.

The IQ in the older children (4-9 years of age) moved after two cell transplantations from the 25 to 49 points-range to 50-69 point-range, and the difference was statistically significant. A decreased hyperactivity, improvement of impaired concentration, lessened stereotypia and behavioral inertia, and improved speech expressivity, were observed already after the 1st cell transplantation, and the difference was statistically significant.

Volume of auditory/visual memory, productivity of thinking in categories, acoustic gnosis, and optic/spatial gnosis, were improved, but not significantly. After cell transplantation, there was an improvement in motor area, particularly in fine coordinated movements, and in self – care habits, that were not psychometrically tested. There was an absence of paroxysmal activity on EEG.

Patients under 4 years of age were treated by human fetal transplantation of brain cortex, mesencephalon, diencephalon, and parietal lobe of brain, while patients older than 4 year of age received also cell transplants of frontal lobe of brain and occipital lobe of brain.

After the publication of the report, the Down's Syndrome project in Moscow continued, and altogether 350 patients were treated.

COMPLETELY CORRECTED

Immune system deficiency of Down's Syndrome can be completely corrected. In our study of two age-matched groups of patients with Down's Syndrome, carried out at the pediatric hospital specialized in genetic and chromosomal aberrations in Moscow, one group of 6 Down's Syndrome patients was treated every 6 months altogether three times by transplantation of human fetal cells of medulla alba of brain, brain cortex, and cerebellum, and the other group of 7 received implantation of saline. Height and weight, head circumference, psychological evaluation, laboratory tests: CBC, serum proteins, calcium, phosphorus, SGOT, SGPT, alkaline phosphatase, and immunoglobulins, were measured. Already after 6 months, just before the 2nd cell transplantation, we had to re-evaluate the situation as 3 of 7 children in the control group were dead due to infections, while in the treated group all children were well. In the controlled group there was an increase of IgG and a marked decrease of IgA and IgM. In the treated group there was a mild decrease of IgG and an increase of IgA and IgM. The decreases of IgA from 166 to 85, and IgM from 140 to 74, in the control group, were signs of immune system deficiency responsible for the death of 3 out of 7 infants, while the marked increase of IgG from 459 to 872 might have been an expression of recurrent infections.

The transplantation of human fetal cells apparently stimulated the immune system, as the levels of IgA increased from 68 to 83, and of IgM from 101 to 111, and that of IgG decreased from 551 to 463, which may be an indication of lesser frequency and severity of bacterial infections. A markedly improved immune system function in treated patients was a result of one treatment by cell transplantation only, and in that treatment only fetal cells of three parts of brain were implanted and no cells of immune system organs whatsoever.

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THE TREATMENTS

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THE PROCEDURE & THE PROGRAM

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